Geoff Dilly and colleagues in the Messing Lab just published a research article n Brain Behavior and Immunity entitled "Knockdown of Tlr3 in dorsal striatum reduces ethanol consumption and acute functional tolerance in male mice". This work investigated the role of toll-like receptor 3 (TLR3), a receptor that is involved in inflammatory pathways in the brain, in ethanol consumption and tolerance. By conditionally knocking out TLR3 in specific brain regions of a mouse, the authors provided evidence that TLR3 signaling in the dorsal striatum affected acute behavioral responses to ethanol that impacted voluntary drinking.
Dilly GA, Blednov YA, Warden AS, Ezerskiy L, Fleischer C, Plotkin JD, Patil S, Osterndorff-Kahanek EA, Mayfiield J, Mayfield RD, Homanics GE and Messing RO. Kno. ckdown of Tlr3 in dorsal striatum reduces ethanol consumption and acute functional tolerance in male mice. Brain, Behavior, and Immunity. 2024. 118:437-448
