Button to scroll to the top of the page.

Hiroshi Nishiyama

Associate Professor
Department of Neuroscience

The formation, maintenance, and rewiring of neuronal circuits in the brain


Phone: 512-232-8438

Office Location

Postal Address
100 E 24TH ST
AUSTIN, TX 78712


Kyoto University, Japan (1992-1996) B.S.

Kyoto University, Japan (1996-1998) M.S.

Kyoto University & RIKEN Brain Science Institute, Japan (1998-2002) Ph.D.

Johns Hopkins University, Baltimore MD (2002-2008) Postdoctoral


Current Research Interest:

The formation, maintenance, and rewiring of synaptic connections in the mammalian brain. In particular, how axonal innervations to postsynaptic targets are: (1) refined during brain development, and (2) reorganized in adulthood with learning and memory, and (3) with brain injury.


Nishiyama H, Nishiyama N, & Zemelman BV. Loss of Purkinje cells in the developing cerebellum strengthens the cerebellothalamic synapses. bioRxiv (2023)

Dey MR, Reddy K, Yoshida H, Nishiyama N, Zemelman BV, & Nishiyama H. Granule cells constitute one of the major neuronal subtypes in the molecular layer of the posterior cerebellum. eNeuro 9(3):ENEURO.0289-21.2022 (2022)

Dhar M, Hantman AW, & Nishiyama H. Developmental pattern and structural factors of dendritic survival in cerebellar granule cells in vivoScientific Reports 8, 17561 (2018)

Dhar M, Brenner JM, Sakimura K, Kano M, & Nishiyama H. (2016) Spatiotemporal dynamics of lesion-induced axonal sprouting and its relation to functional architecture of the cerebellum. Nature Communications 7, 12938 (2016)

Nishiyama H. Dendritic translocation of climbing fibers: a new face of old phenomenon. Cerebellum 14, 1-3 (2015)

Nishiyama H. Learning-induced structural plasticity in the cerebellum. International Review of Neurobiology 117, 1-19 (2014)

Nishiyama N, Colonna J, Shen E, Carrillo J, & Nishiyama H. Long-term in vivo time-lapse imaging of synapse development and plasticity in the cerebellum. Journal of Neurophysiology 111, 208-216 (2014)

Carrillo J, Cheng SY, Ko KW, Jones TA, & Nishiyama H. The long-term structural plasticity of cerebellar parallel fiber axons and its modulation by motor learning. Journal of Neuroscience 33, 8301-8307 (2013)

Carrillo J, Nishiyama N, & Nishiyama H. Dendritic translocation establishes the winner in cerebellar climbing fiber synapse elimination. Journal of Neuroscience 33, 7641-7653 (2013)

Kim HS, Seto-Ohshima A, Nishiyama H, & Itohara S. Normal delay eyeblink conditioning in mice devoid of astrocytic S100B. Neuroscience Letters 489, 148-153 (2011)

Tanaka M, Yamaguchi K, Tatsukawa T, Nishioka C, Nishiyama H, Theis M, Willecke K, & Itohara S. Lack of Connexin43-mediated bergmann glial gap junctional coupling does not affect cerebellar long-term depression, motor coordination, or eyeblink conditioning. Frontiers in Behavioral Neuroscience 2, 1-14(2008)

Nishiyama H, Fukaya M, Watanabe M, & Linden DJ. Axonal motility and its modulation by activity are branch-type specific in the intact adult cerebellum. Neuron 56, 472-487 (2007)

Nishiyama H, & Linden DJ. Pure spillover transmission between neurons. Nature Neuroscience 10, 675-677 (2007)

Nishiyama H, & Linden DJ. Differential maturation of climbing fiber innervation in cerebellar vermis. Journal of Neuroscience 24, 3926-3932 (2004)

Takemura M, Nishiyama H, & Itohara S. Distribution of phosphorylated glial fibrillary acidic protein in the mouse central nervous system. Genes to Cells 7, 295-307 (2002)

Nishiyama H, Takemura M, Takeda T, & Itohara S. Normal development of serotonergic neurons in mice lacking S100B. Neuroscience Letters 321, 49-52 (2002)

Nishiyama H, Knopfel T, Endo S, & Itohara S. Glial protein S100B modulates long-term neuronal synaptic plasticity. Proceedings of the National Academy of Sciences of the United States of America 99, 4037-4042 (2002)

Iwasato T, Datwani A, Wolfe AM, Nishiyama H, Taguchi Y, Tonegawa S, Knöpfel T, Erzurumlu RS, & Itohara S. Cortex-restricted disruption of NMDAR1 impairs neuronal patterns in the barrel cortex. Nature 406, 726-731 (2000)