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Hiroshi Nishiyama

Associate Professor
Department of Neuroscience

The formation, maintenance, and rewiring of neuronal circuits in the brain


Phone: 512-232-8438

Office Location

Postal Address
The University of Texas at Austin
100 E 24TH STREET, Stop C7000
AUSTIN, TX 78712


Kyoto University, Japan (1992-1996) B.S.

Kyoto University, Japan (1996-1998) M.S.

Kyoto University & RIKEN Brain Science Institute, Japan (1998-2002) Ph.D.

Johns Hopkins University, Baltimore MD (2002-2008) Postdoctoral


Current Research Interest:

The formation, maintenance, and rewiring of synaptic connections in the mammalian brain. In particular, how axonal innervations to postsynaptic targets are: (1) refined during brain development, and (2) reorganized in adulthood with learning and memory, and (3) with brain injury.


Dhar, M., Brenner, J.M., Sakimura, K., Kano, M., & Nishiyama, H. (2016) Spatiotemporal dynamics of lesion-induced axonal sprouting and its relation to functional architecture of the cerebellum. Nature Communications 7, 12938 doi: 10.1038/ncomms12938

Nishiyama, H. (2015) Dendritic translocation of climbing fibers: a new face of old phenomenon. Cerebellum 14, 1-3

Nishiyama, H. (2014) Learning-induced structural plasticity in the cerebellum. International Review of Neurobiology 117, 1-19

Nishiyama, N., Colonna, J., Shen, E., Carrillo, J., & Nishiyama, H. (2014) Long-term in vivo time-lapse imaging of synapse development and plasticity in the cerebellum. Journal of Neurophysiology 111, 208-216.    

Carrillo, J., Cheng, S. Y., Ko, K. W., Jones, T. A., & Nishiyama, H. (2013) The long-term structural plasticity of cerebellar parallel fiber axons and its modulation by motor learning. Journal of Neuroscience 33, 8301-8307.

Carrillo, J., Nishiyama, N., & Nishiyama, H. (2013) Dendritic translocation establishes the winner in cerebellar climbing fiber synapse elimination. Journal of Neuroscience 33, 7641-7653.

Kim, H. S., Seto-Ohshima, A., Nishiyama, H., & Itohara, S. (2011) Normal delay eyeblink conditioning in mice devoid of astrocytic S100B. Neuroscience Letters 489, 148-153.

Tanaka, M., Yamaguchi, K., Tatsukawa, T., Nishioka, C., Nishiyama, H., Theis, M., Willecke, K., & Itohara, S. (2008) Lack of Connexin43-mediated bergmann glial gap junctional coupling does not affect cerebellar long-term depression, motor coordination, or eyeblink conditioning. Frontiers in Behavioral Neuroscience 2, 1-14.

Nishiyama, H., Fukaya, M., Watanabe, M., & Linden, D. J. (2007) Axonal motility and its modulation by activity are branch-type specific in the intact adult cerebellum. Neuron 56, 472-487.

Nishiyama, H., & Linden, D. J. (2007) Pure spillover transmission between neurons. Nature Neuroscience 10, 675-677.

Nishiyama, H., & Linden, D. J. (2004) Differential maturation of climbing fiber innervation in cerebellar vermis. Journal of Neuroscience 24, 3926-3932.

Takemura, M., Nishiyama, H., & Itohara, S. (2002) Distribution of phosphorylated glial fibrillary acidic protein in the mouse central nervous system. Genes to Cells 7, 295-307.

Nishiyama, H., Takemura, M., Takeda, T., & Itohara, S. (2002) Normal development of serotonergic neurons in mice lacking S100B. Neuroscience Letters 321, 49-52.

Nishiyama, H., Knopfel, T., Endo, S., & Itohara, S. (2002) Glial protein S100B modulates long-term neuronal synaptic plasticity. Proceedings of the National Academy of Sciences of the United States of America 99, 4037-4042.

Iwasato, T., Datwani, A., Wolfe, A.M., Nishiyama, H., Taguchi, Y., Tonegawa, S., Knöpfel, T., Erzurumlu, R.S., & Itohara, S. (2000) Cortex-restricted disruption of NMDAR1 impairs neuronal patterns in the barrel cortex. Nature 406, 726-731.