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Brumback, Audrey

Audrey C Brumback

Assistant Professor of Neurology, Assistant Professor (Medical)
Department of Neurology, Department of Pediatrics


Phone: 512-495-5241

Office Location
NHB 2.122

Postal Address
100 E 24TH ST
AUSTIN, TX 78712

I grew up in Norman, Oklahoma. I “defected” to go to UT Austin for undergrad. I was a Dean’s Scholar and graduated with a Bachelors of Science in Biochemistry. During college, I studied abroad for one year in Santiago de Compostela, Spain. I then graduated from the Medical Scientist Training Program at the University of Colorado Health Sciences Center in Denver. I earned my PhD in Neuroscience in 2006 and my MD in 2008. For my PhD, I studied how the newborn brain differs from the adult brain in how electrical signals are transmitted, and how these differences can lead to seizures in infants. I completed Pediatrics internship at the University of California, San Francisco (UCSF) followed by Child Neurology residency via the Neuroscience Pathway, a special training program for physician-scientists. I am certified by the American Board of Psychiatry and Neurology in Neurology with Special Qualifications in Child Neurology. Following residency, I joined the faculty at UCSF and gained further subspecialty scientific training in the lab of Dr. Vikaas Sohal studying how the brain’s electrical activity is altered in autism. I also gained special clinical expertise in autism spectrum disorder through treating patients at the UCSF Pediatric Brain Center’s Sensory, Neurodevelopment, and Autism Program. In addition, I was the Child Neurologist for Katie’s Clinic for Rett Syndrome and Related Disorders at UCSF Benioff Children’s Hospital – Oakland. I am fluent in Spanish, and serve as the Child Neurologist for Rotary Club’s Proyecto Niño, an annual medical service mission in Mexico.


I joined the Departments of Neurology and Pediatrics at Dell Med in January of 2017. My time is split between scientific investigations and seeing patients. Clinically, I specialize in the evaluation and treatment of children with autism spectrum disorder and other neurodevelopmental disabilities. Scientifically, I use a diverse array of approaches such as optogenetics, calcium imaging, behavioral assays, and patch clamp electrophysiology to understand how the brain’s circuitry is disrupted in disorders like autism. My long-term goal is to develop circuit-based therapies to improve the lives of people with autism and related neurodevelopmental disorders.

Martin P-M*, Stanley RE*, Ross AP#, Freitas AE#, Moyer, CE, Brumback AC, Iafrati J, StaCENSOREDwongkul KS, Dominguez S, Kivimae S, Mulligan KA, Pirooznia M, McCombie WR, Potash JB, Zandi PP, Purcell SM, Sanders SJ, Zuo Y, Sohal VS, Cheyette BNR. DIXDC1 contributes to psychiatric susceptibility by regulating dendritic spine and glutamatergic synapse density via GSK3 and Wnt/β-catenin signaling. Molecular Psychiatry advance online publication 18 October 2016; PMID: 27752079. 

Brumback AC, Staley KJ. Thermodynamic regulation of NKCC1-mediated Cl− cotransport underlies plasticity of GABAA signaling in neonatal neurons. Journal of Neuroscience 2008; 28:1301-1312. PMID: 18256250. 

Dzhala VI, Brumback AC, Staley KJ: Bumetanide enhances phenobarbital efficacy in a neonatal seizure model. Annals of Neurology 2008; 63:222-35. PMID: 17918265 

Dzhala VI, Talos DM, Sdrulla DA, Brumback AC, Mathews GC, Benke TA, Delpire E, Jensen FE, Staley KJ. NKCC1 transporter facilitates seizures in the developing brain. Nature Medicine 2005; 11:1205-